Functions of Prdm16 in thermogenic fat cells

Functions of Prdm16 in thermogenic fat cells.

The PR-domain containing 16 (Prdm16) protein is a powerful inducer of the thermogenic phenotype in fat cells. In both developmental (brown) and induced (beige) thermogenic adipose tissue, Prdm16 has a critical role in maintaining proper tissue structure and function. It has roles throughout the course of differentiation, beginning with lineage determination activity in precursor cells, and cont...

PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression.

How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear. Our previous studies suggest that PexRAP, a peroxisomal lipid synthetic enzyme, regulates PPARγ signaling and white adipogenesis. Here, we show that PexRAP is an inhibitor of brown adipocyte gene expression. Pe...

evaluation of fat atrophy in patients with dermis fat graft of orbit by ct-scan

چکیده ندارد.

Thermogenic mechanisms in brown fat.

Editorial: Molecular Regulation and Therapeutic Potential of Thermogenic Fat Cells

Much of systemic metabolism depends on the activity and function of adipose tissue. Adipocytes in mammals fall into two categories classified by their primary functions: white fat cells that mediate energy storage and thermogenic fat cells that counteract hypothermia and obesity through adap-tive thermogenesis. Whereas white fat and its function as an energy reservoir and endocrine organ have b...